Novel risk loci for COVID-19 hospitalization among admixed American populations

Novel risk loci for COVID-19 hospitalization among admixed American populations

Blog Article

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified.However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci.In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 here Host Genetic Initiative.

We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS).A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP.Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.

This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date.This allowed to reveal novel risk loci and emphasize the need of depileve easy clean considering the diversity of populations in genomic research.